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Post by Jean-Marie Bassett - Moderator on Dec 21, 2015 8:19:11 GMT
Do we have sufficient choices available to develop downstream processing methodologies that can match the flow-rates of product streams emanating from continuous flow reactor systems ? What do you think?
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Post by Alain Merschaert on Jan 12, 2016 7:47:58 GMT
From our experience we found this the current bottleneck for integrated continuous manufacturing (reaction + work-up + product purification/isolation) also preventing or at least making very difficult the combination of several chemical steps in flow. We currently only perform the reaction in flow and rely on batch processing for work-ups, purifications and isolation. Significant development of scalable solutions is to me a key to the future of continuous flow manufacturing
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Post by Andrea Adamo on Jan 19, 2016 3:22:28 GMT
Alain, thanks for sharing your thoughts. I'm wondering if the liquid-liquid separation technology we have developed could assist you in your in line workup. Some information is at www.zaiput.com I'd be happy to follow up with literature and more information if of interest. |
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Post by Nathalie Douillet on Jan 20, 2016 13:42:47 GMT
Technologies enabling solvent swap without the need for concentration to dryness as well as dehydration technologies would be beneficial for a faster, more straight-forward implementation of telescoped synthesis. I would be grateful if anyone could share their experience in these areas (especially around scalable solutions)
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Post by Rudi Oliveira on Jan 21, 2016 8:55:32 GMT
I agree with Nathalie, in the event you plan to telescope several steps, solvent swap becomes hard to avoid. If you need to work with high boiling point solvents like water, things get even more difficult.
It would also be great to include precipitation (not talking about crystallization) into continuous, but that is a greater battle.
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Post by Jean-Marie Bassett - Moderator on Feb 1, 2016 19:40:07 GMT
Good contributions so far with Nathalie throwing down a clear challenge:
I feel this opens up a new question : do we analyse and break down the downstream operations into different types/manipulations and invite inventors to come up with solutions for each, or, do we try for a more holistic approach? Regarding Rudi's comment : where does precipitation stop and crystallisation begin?? technologies for continuous crystallisation and purification do exist.
I think this discussion can deliver some very interesting points that could impinge on creative research as well as innovative equipment supply.
Who can give the next twist to this chat?
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Post by Jean-Marie Bassett - Moderator on May 9, 2016 14:09:27 GMT
Here is my question to all readers:-
Are there sufficient companies offering technology solutions addressing the complete value chain of chemicals to be made by continuous flow?
(This includes downstream processing and in-line analytical services.)
We hope that a large number of views on this can be collected.
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